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SYSTEM AND METHOD FOR ANALYZING EXTRACELLULAR VESICLES WITH AN OPTICAL BIOSENSOR
SYSTEM AND METHOD FOR ANALYZING EXTRACELLULAR VESICLES WITH AN OPTICAL BIOSENSOR
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机译:用光学生物传感器分析细胞外囊的系统和方法
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摘要
Various implementations of a system and method for analyzing extracellular vesicles (EVs) are disclosed having a number of innovative features. In one implementation, a method for analyzing EVs includes binding EVs to an optical waveguide biosensor and phenotyping the bound EVs. Phenotyping can include binding a labeled ligand to the EVs and/or rupturing the EVs and analyzing their cargo. In another implementation, a system for analyzing EVs includes EVs bound to an optical waveguide biosensor and a labeled ligand bound to the EVs. In another implementation, a kit for analyzing EVs includes a micro plate having wells containing optical waveguide biosensors functionalized with a binding agent configured to bind to EVs and at least one of: (a) labeled ligands configured to bind to the extracellular vesicles or (b) a reagent configured to rupture the extracellular vesicles.
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