BLOCKADE OF CD2-OEBROADCAST EXPRESSION AND EXPRESSION OF CHIMICAL ANTIGENRECEPTORS FOR THE IMMUNTHERAPY OF T-CELL MALIGNOMS

摘要

The present invention provides engineered immune cells comprising an anti-CD2 protein expression blocker (PEBL) and an anti-CD2 chimeric antigen receptor (CAR). In some embodiments, such engineered immune cells lack surface expression CD2. Also, provided herein are methods of using such cells in cancer therapies.