ANIMAL MODELS AND SCREENING PROCEDURES FOR INTRAOCULAR DISEASES OR DISORDERS

摘要

Provided are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD). For example, provided are screening methods for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. The screening method can be an in vitro screening method or an in vivo screening method, e.g., using an animal model described. Animal models are also provided herein, for example, for screening candidate therapeutics for treating or preventing eye diseases, such as AMD. Methods of preparing the animal models are also described.