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Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant P53
Peptides and use of same in the treatment of diseases, disorders or conditions associated with a mutant P53
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机译:肽和用途在治疗与突变体p53相关的疾病,疾病或病症中
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摘要
An isolated peptide is provided. The peptide comprises an amino acid sequence arranged in a space and configuration that allow interaction of the peptide with the DNA Binding Domain (DBD) of p53 through at least one residue of the DBD by which pCAP 250 (SEQ ID NO: 1) binds the DBD, wherein the peptide at least partially reactivates a mutant p53 protein, with the proviso that the peptide is not SEQ ID NO: 59-382.
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机译:提供了分离的肽。 肽包含布置在空间和构型中的氨基酸序列,其允许肽与P53的DNA结合结构域(DBD)的相互作用,所述DBD的至少一种残基(SEQ ID NO:1)结合 DBD,其中肽至少部分地重新激活突变体P53蛋白,其中肽不是SEQ ID NO:59-382的条件。
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