The present disclosure relates to a system for prevention of sudden death that includes a wearable seizure detection device; a base unit; and a computer, the computer configured to receive input from the seizure detection device and trigger the base unit to release oxygen under a condition effective to enrich an environmental oxygen level and prevent sudden death when the input indicates a seizure. Also disclosed is a portable system for preventing sudden death, where the system includes an oronasal mask; a compressed oxygen cartridge, wherein the compressed oxygen cartridge is coupled to the oronasal mask; and a fastener, wherein the fastener is coupled to the oronasal mask, wherein the system releases oxygen upon activation under a condition effective to enrich an environmental oxygen level and prevent sudden death. Further disclosed are methods of preventing sudden death comprising enriching an environmental oxygen level for a subject using the systems described.
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