Characteristics of cardiac asynchrony and non-synergy

摘要

A method for identifying reversible cardiac desynchronization in a patient is disclosed. The method uses measurement of an event associated with a rapid increase in the rate of increase in pressure in the left ventricle, the method comprising: a first time delay between the event associated with the rapid increase in the rate of increase in pressure in the left ventricle and a first reference time calculating via: the one or more sensors to measure a time at which the event associated with the rapid increase in the rate of increase in pressure in the left ventricle occurs by identifying a characteristic response in data received from the one or more sensors; using the data received from ), wherein the event associated with the rapid increase in the rate of increase in pressure in the left ventricle is identifiable at each contraction of the heart; the same sensor(s), or the one or more sensors, to determine a first time delay between the first reference time and the measured time of the identified characteristic response in relation to the rapid increase in the rate of increase in pressure in the left ventricle processing signals from one or more other sensors of (s); measuring a biopotential indicative of electrical activation of the heart; comparing the first time delay between the first reference time and the measured time of the identified characteristic response in relation to the rapid increase in the rate of pressure increase in the left ventricle to a period of electrical activation of the heart. If the first time delay is longer than a set portion of the electrical activation of the heart, the presence of cardiac desynchronization in the patient is identified. pacing is applied to the patient's heart, and calculating a second time delay between the identified characteristic response in relation to the rapid increase in the rate of increase in pressure in the left ventricle after pacing and a second reference time after pacing by the following steps become: using at least one sensor to measure the timing of the identified characteristic response in relation to the rapid increase in the rate of increase in pressure in the left ventricle after pacing; and from the one or more sensor(s) to determine the second time delay between the second reference time after pacing and the determined time of the identified characteristic response in relation to the rapid increase in the rate of pressure increase in the left ventricle. processing the signal; comparing the first time delay and the second time delay; wherein, when the second time delay is shorter than the first time delay, the period to the onset of myocardial synergy, the shortening of the delay to OoS is identified and the period to the point at which all segments of the heart begin to stiffen actively or passively is shortened and thus identifying the presence of reversible cardiac desynchronization in the patient.