Blood-brain barrier penetration aptamer and use thereof

摘要

The present invention relates to an aptamer capable of penetrating the blood-brain barrier (BBB) and capable of receptor-mediated transcytosis and use thereof. The aptamer of the present invention selectively targets only the transferrin receptor protein, passes through the BBB rapidly through receptor-mediated cell internalization, and efficiently transports various therapeutic agents such as proteins, antibodies, nucleic acids and small-molecular compounds through simple chemical bonding And it can deliver, shows cross-reactivity at the transferrin receptor between species, and is easy to chemically modify, so it can be applied as a drug delivery agent in neurological diseases, particularly brain and central nervous system diseases.