CENTRAL MEMORY T-CELLS FOR ADOPTIVE T-CELL THERAPY

摘要

FIELD: biotechnology.;SUBSTANCE: present invention relates to biotechnology and is a population of human T-cells transduced by a vector expressing a chimeric antigen receptor for the treatment of glioma/glioblastoma. More than 50% of the transduced cells in this population are central memory T-cells, in particular CD45R0+, CD62L+, and CD45Ra- T-cells. This population is used to prepare a pharmaceutical composition for the treatment of glioma/glioblastoma. ;EFFECT: present invention makes it possible to obtain a means for tumor-specific therapy with a longer-term antitumor function. ;12 cl, 5 tbl, 9 ex, 15 dwg