IMMUNOGENIC FRANCISELLA ANTIGENS AND THEIR USE IN IMMUNIZATION OF FISH AGAINST FRANCISELLOSIS

摘要

Immunogenic compositions that elicit immune responses against Francisella orientalis antigens are provided. In particular, immunogenic compositions comprising Francisella orientalis IglC and/or GroEL immunogenic polypeptides and/or recombinant polynucleotides encoding the Francisella orientalis IglC and/or GroEL immunogenic polypeptides, and/or microalgae expressing the Francisella orientalis IglC and/or GroEL immunogenic polypeptides are provided. Immunogenic compositions may further comprise other Francisella orientalis immunogenic polypeptides and/or immunogenic polypeptides from other pathogens causing disease in fish. The immunogenic compositions may also include one or more adjuvants. Additionally, methods of using the immunogenic compositions in applications including immunization and vaccination are provided.