ADENO-ASSOCIATED VIRUS AND THE USE THEREOF IN PREPARING MEDICATIONS FOR TREATING COCAINE ADDICTION

摘要

Provided is a shRNA having a target sequence represented by SEQ ID NO. 1, and said shRNA sequence is the RNA form of SEQ ID NO. 3 or 4. Also provided are a double-stranded oligonucleotide comprising the SEQ ID NO. 1 sequence, a double-stranded oligonucleotide formed by complementary base pairing of single-stranded oligonucleotides represented by sequences such as SEQ ID NO. 3 and SEQ ID NO. 4, a recombinant adeno-associated virus carrying said double-stranded oligonucleotide and the RNA form thereof, and the use thereof in preparing medications for reducing cocaine addiction.