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METHOD FOR PREPARING DONEPEZIL-CONTAINING SUSTAINED-RELEASE PLGA MICROSPHERES
METHOD FOR PREPARING DONEPEZIL-CONTAINING SUSTAINED-RELEASE PLGA MICROSPHERES
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机译:制备含有多哌齐的缓释PLGA微球的方法
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摘要
The present invention relates to a method for preparing donepezil-containing sustained-release PLGA microspheres and, more specifically, to a method for preparing donepezil-containing sustained-release PLGA microspheres comprising the steps of: i) preparing microsphere droplets by injecting a dispersed phase comprising donepezil or a pharmaceutically acceptable salt thereof, poly(lactic-co-glycolic acid) (PLGA), and an organic solvent into a microfluidic chip; and ii) dispersing the microsphere droplets into a water phase of 15-20℃ comprising a surfactant. The method for producing donepezil-containing sustained-release PLGA microspheres of the present invention can produce sustained-release microspheres having high production reproducibility while containing a high content of donepezil, and thus can be used for production of safe and stable therapeutic agents and the like.
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