Inhibition of Lysine Demethylase 1 (Lsd1) Induces Differentiation of Hair Cells

摘要

Methods for the generation of sensorineural hair cells, and more particularly to the use of epigenetic modulation of Atoh1 expression using a combination of Histone Lysine Demethylase (KDM) inhibitors and Wnt activators to generate sensorineural hair cells.