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RNA-GUIDED DNA INTEGRATION USING TN7-LIKE TRANSPOSONS
RNA-GUIDED DNA INTEGRATION USING TN7-LIKE TRANSPOSONS
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机译:使用TN7类似的转座子的RNA引导的DNA集成
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摘要
In certain embodiments, the present systems and methods use Tn7-like transposons that encode CRISPR-Cas systems for programmable, RNA-guided DNA integration. For example, the CRISPR-Cas machinery directs the Tn7 transposon-associated proteins to integrate DNA downstream of a target site (e.g., a genomic target site) recognized by a guide RNA (gRNA).
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