Tolerant synthetic nanocarriers for antigen-specific deletion of T-effector cells

摘要

PROBLEM TO BE SOLVED: To provide a new immunosuppressive drug therapy for causing immunosuppression associated with an undesired immune response. Synthetic nanos comprising administration of an immunosuppressive drug to an MHC class I-restricted and / or MHC class II-restricted epitope capable of producing a tolerant immune response (eg, antigen-specific T-effector cell deletion). Carrier methods and related compositions are provided. [Selection diagram] FIG. 5