Compositions and Methods for Tumor Vaccination Using Prostate Cancer-Related Antigens

摘要

PROBLEM TO BE SOLVED: To provide a method and a composition for constructing and producing a vector vaccine based on recombinant adenovirus. A highly reactive anti-adenovirus vector containing genes for target antigens such as prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA), MUC1, CEA, and / or Brachyury. Provided are compositions and methods comprising co-stimulatory molecules for use in therapeutic methods that generate a tumor immune response and allow multivalent vaccination in individuals with pre-existing immunity to adenovirus. [Selection diagram] FIG. 10