An apparatus in one embodiment comprises a host device configured to communicate over a network with a storage system comprising a plurality of storage devices. The host device comprises a set of input-output queues and a multi-path input-output driver configured to select input-output operations from the set of input-output queues for delivery to the storage system over the network. The multi-path input-output driver is further configured to send a predetermined command to the storage system over each of a plurality of paths from the host device to the storage system, to monitor a response time for the predetermined command on each of the paths, and to detect a performance issue with at least a given one of the paths based at least in part on the monitored response time. The predetermined command illustratively comprises a Small Computer System Interface (SCSI) “immediate” command of a particular type, such as a Test Unit Ready (TUR) command.
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