THIAZOLIDINEDIONE COMPOUNDS FOR TREATMENT OF DRUG RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA

摘要

Cell death may be induced in a cancer cell line, by treating the cancer cell line with a compound of formula (I), a compound of formula (II), pharmaceutically acceptable salts thereof, mixtures thereof, enantiomers thereof, or racemates thereof: wherein X is a chacogen, e.g., O, S, or Se; NH; NR5, where R5 is a C1 to C8 alkyl group or a C1 to C8 acyl group; BR6, where R6 is a halogen, e.g., fluorine, bromine, or iodine, H, lower alkyl, or lower alkoxy; or Si(R7)2, where R7 is a C1 to C8 alkyl group or a C1 to C8 acyl group; and R1, R2, R3, and R4 are independently hydrogen, a C1 to C8 alkyl group, hydroxy, alkoxy, aryloxy, acyloxy, a thiol group, a thioalkyl group, a thioacyl group, an a sulfonamide group, an amino group, a mono- or dialkylamino group, an acylamino group, or a halogen.