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HIGH CONCENTRATION FORMULATION OF FACTOR XII ANTIGEN BINDING PROTEINS
HIGH CONCENTRATION FORMULATION OF FACTOR XII ANTIGEN BINDING PROTEINS
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机译:因子XII抗原结合蛋白的高浓度制剂
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摘要
The present application is directed to a liquid formulation comprising at least 100mg/ml of a protein comprising an antigen binding domain that binds to FXII (and/or an activated form thereof), an organic buffer, a non-ionic surfactant and an amino acid stabilizer, wherein the pH of the formulation is 5.0-6.5 and the viscosity is less than 30 mPa*s at 20°C. Exemplary formulations comprise the specific Factor XII antibody 3F7, in formulation with a histidine buffer, a polysorbate 80 surfactant and the amino acid stabilizers arginine and proline.
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