CRYSTALS OF ALKYNYL-CONTAINING COMPOUND, SALT AND SOLVATE THEREOF, PREPARATION METHOD, AND APPLICATIONS

摘要

Disclosed are crystals of an alkynyl-containing compound, a salt and a solvate thereof, a preparation method, and applications. Specifically disclosed are crystal I of 3-(1H-pyrazole[3,4-b]pyridine-5-substituted)ethynyl)-4-methyl-N-(4-((4-methylpiperazine-1-substituted)methyl)-3-(trifluoromethyl)phenyl)benzamide and crystal II of 3-((1H-pyrazole[3,4-b]pyridine-5-substituted)ethynyl)-4-methyl-N-(4-((4-methylpiperazine-1-substituted)methyl)-3-(trifluoromethyl)phenyl)benzamide fumarate. The crystals of the present invention have excellent stability and provide a significant value with respect to the optimization and development of a medicament.