An imaging surface plasmon resonance apparatus comprises: a prism; a two dimensional vertical-cavity surface-emitting laser array; a layer of metal; and a detector. The two dimensional vertical-cavity surface-emitting laser array is operable to produce a two dimensional array of beams of electromagnetic radiation and is arranged such that each one of said two dimensional array of beams of electromagnetic radiation is coupled into the prism and is incident on a different one of a plurality of regions on a surface of the prism. The beams of electromagnetic radiation in the two dimensional array of beams of electromagnetic radiation may be generally mutually parallel. The layer of metal is disposed on or adjacent to the surface of the prism in the vicinity of each of the plurality of regions on the surface of the prism. The layer of metal may comprise a two dimensional array of receptor sites for supporting a receptor, each receptor site disposed on a surface of the layer of metal that is distal to the prism and adjacent one of the plurality of regions on the surface of the prism. The detector is arranged to receive a portion of each of the plurality of beams of electromagnetic radiation which is reflected from the interface between the prism and the layer of metal and operable to determine an intensity of said portion of each of the plurality of beams of electromagnetic radiation.
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