NUCLEIC ACID WATERMARKS TO ASSESS AND IMPROVE NUCLEIC ACID-GUIDED NUCLEASE OR NICKASE FUSION EDITING

摘要

The present disclosure relates to compositions, methods, modules and automated integrated instrumentation to make auxiliary or ancillary edits—in addition to intended edits and immunizing edits—in cellular genomic nucleic acids in order to assess and improve nucleic acid-guided nuclease or nickase fusion editing.