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LARGE-SCALE PRODUCTION OF EXOSOMES FROM PRIMED MESENCHYMAL STROMAL CELLS FOR CLINICAL USE
LARGE-SCALE PRODUCTION OF EXOSOMES FROM PRIMED MESENCHYMAL STROMAL CELLS FOR CLINICAL USE
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机译:从灌注间充质基质细胞的大规模生产外泌体进行临床用途
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摘要
Embodiments of the disclosure encompass systems, methods, and compositions for producing exosomes from primed mesenchymal stem cells that are expanded in the presence of IFNγ, TNFα, IL-1β, and IL-17. The systems, methods, and compositions may occur in an automated cell expansion system that allows for controllable parameters and from which cells and exosomes may be harvested at one or more times as part of a particular regimen. In specific embodiments, the exosomes may be provided to an individual in need thereof, including in some cases when the exosomes comprise one or more therapeutic agents.
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