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CELL PENETRATING SHORT PEPTIDE TAT-HUR-HNS-3 AND APPLICATION THEREOF IN INFLAMMATORY DISEASE
CELL PENETRATING SHORT PEPTIDE TAT-HUR-HNS-3 AND APPLICATION THEREOF IN INFLAMMATORY DISEASE
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机译:细胞穿透短肽TAT-HUN-HNS-3及其在炎性疾病中的应用
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摘要
The present disclosure relates to a cell penetrating short peptide TAT-HuR-HNS-3 and application thereof in inflammatory disease, wherein the amino acid sequence of cell penetrating short peptide TAT-HuR-HNS-3 for inflammatory diseases caused by elevated inflammatory factors is YGRKKRRQRRR-SPMGVDHMSGLSGVNVPGNASSG, the inflammatory diseases caused by elevated inflammatory factors include lung inflammation, asthma, pollen allergy, and nephritis; TAT-HuR-HNS-3 may specifically inhibit the interaction of HuR-PARP1/HuR-HuR and the expression of inflammatory factors, and has no effect on cell proliferation and survival. This provides a safety guarantee for the drug development of cell penetrating peptides, and is a new method applied to the treatment of inflammatory diseases.
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