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VIRION DISPLAY ARRAY FOR PROFILING FUNCTIONS AND INTERACTIONS OF HUMAN MEMBRANE PROTEINS
VIRION DISPLAY ARRAY FOR PROFILING FUNCTIONS AND INTERACTIONS OF HUMAN MEMBRANE PROTEINS
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机译:病毒群岛显示阵列,用于分析人膜蛋白的分析功能和相互作用
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摘要
Provided herein are recombinant virion arrays comprising human membrane bound proteins that retain their native conformations and/or interactions, recombinant HSV-1 virions, and methods of use including high-content, high-throughput assays for screening for ligands and/or drugs that bind human membrane bound proteins, diagnostic assays, proteomic assays, and biosensor assays. Also provided are recombinant HSV-1 virions comprising an envelope comprising a plurality of heterologous membrane bound proteins that retain their native conformations and/or interactions as well as recombinant HSV-1 bacterial artificial chromosome (BAC) clones encoding heterologous membrane polypeptides.
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