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SYSTEM AND METHOD FOR LIGHT-REGULATED OLIGOMERIZATION AND PHASE SEPARATION OF FOLDED DOMAINS AND RNA GRANULE-ASSOCIATED PROTEIN DOMAINS
SYSTEM AND METHOD FOR LIGHT-REGULATED OLIGOMERIZATION AND PHASE SEPARATION OF FOLDED DOMAINS AND RNA GRANULE-ASSOCIATED PROTEIN DOMAINS
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机译:用于折叠结构域和RNA颗粒相关蛋白域的测量寡聚化和相分离的系统和方法
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摘要
Disclosed is a method and system for the phase separation of folded domains, and more particularly, to inducing clusters of folded domains as part of a drug-based screening application. The system and method utilize one or more first fusion proteins (100, 101), each first fusion protein comprising a first region (110) fused to a second region (120), the first region (110) comprising at least one light sensitive protein (115) or cognate partner of a light sensitive protein (116), and the second region (120) comprising one or more folded RNA binding domains (RBDs), disordered RBDs, folded non-RBD domains, or combination thereof (125).
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