Methods for High Throughput Peptide-MHC Affinity Screening for TCR Ligands

摘要

The present invention relates to a method for high throughput screening of a TCR-binding peptide ligand / MHC molecular complex comprising stabilized peptide-MHC molecules, and the use of each of the above methods. The present invention comprises, a polypeptide comprising or consisting of a stabilized MHC molecule or a peptide bond fragment thereof, a pharmaceutical composition comprising said polypeptide, a vaccine comprising said said pharmaceutical composition, and the manufacture of a drug. And / or further relating to the use of the vaccine for the prevention of cancer. The present invention further relates to nucleic acids encoding the polypeptide, and vectors comprising said nucleic acids.