The present invention relates to an antiviral pharmaceutical composition comprising a polar extract of Astraeus asiaticus, and one or more pharmaceutically acceptable excipient selected from the group consisting of a solvent, an additive, a buffering agent, a preservative, a flavoring agent, and a stabilizer. The composition may further comprise Acyclovir. The invention further relates to use of the composition for treating diseases caused by Enterovirus 71 (EV71), Coxsackies A16 (CAV16), Herpes Simplex Virus type 1 (HSV-1), Herpes Simplex Virus type 2 (HSV-2), and HSV-2 strain resistant to Acyclovir, including hand, foot and mouth disease (HFMD). The invention also relates to use of ergosterol for treating HFMD.
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