KIRIGAMI-INSPIRED STENTS FOR SUSTAINED LOCAL DELIVERY OF THERAPEUTICS

摘要

The present disclosure provides a kirigami-inspired injectable stent system. The stent systems and methods enable radial/ circumferential and longitudinal delivery of an extended release of therapeutics within tubular structures of the body, such as the GI tract and trachea. According to some aspects, a kirigami -based injectable stent system is provided that can enable drug release through deposition of therapeutic-coated needles of the stent in the tubular mucosa, such as often found in the gastrointestinal tract or trachea.