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Treatment of metabolic disorders using a binding protein for gastric inhibitory peptide receptor (GIPR) combined with GLP-1 agonist

机译:使用胃抑制肽受体(GIPR)结合GLP-1激动剂治疗代谢紊乱的代谢紊乱

摘要

Problem to be solved: to provide a method of treating metabolic disorders and metabolic disorders using an antigen binding protein specific for the GIPR polypeptide.A method of treating an object with metabolic disorder and administering an antigen binding protein that is specifically binding to a protein having an amino acid sequence having at least 90% amino acid sequence identity to the amino acid sequence of GIPR, at a therapeutically effective dose .The metabolic disorder is a disorder of glucose metabolism and reduces plasma glucose in the subject.No selection
机译:要解决的问题:提供一种使用针对GIPR多肽的抗原结合蛋白治疗代谢紊乱和代谢紊乱的方法。一种用代谢紊乱治疗物体并施用特异性结合蛋白质的抗原结合蛋白的方法 一种氨基酸序列,在治疗有效剂量下具有GIPR的氨基酸序列具有至少90%的氨基酸序列同一性。代谢紊乱是葡萄糖代谢的疾病,并减少受试者中的血浆葡萄糖。NO选择

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