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Aurora kinase and Janus kinase inhibitors for prevention of graft versus host disease
Aurora kinase and Janus kinase inhibitors for prevention of graft versus host disease
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机译:用于预防移植物与宿主疾病的Aurora激酶和Janus激酶抑制剂
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摘要
Disclosed herein are compounds and methods for reducing the risk of developing, preventing, or treating graft versus host disease (GVHD) in a subject. The compounds can concurrently block Aurora kinase A and JAK2 signal transduction which synergistically suppresses alloreactive human T-cells in vitro, prevents xenogeneic graft-versus-host disease without impairing anti-tumor responses, and promotes the development and suppressive potency of CD39+ inducible Treg. In certain aspects, disclosed are compounds of Formula I-V.;
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