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COMPOSITIONS, METHODS, AND SYSTEMS FOR PATERNITY DETERMINATION
COMPOSITIONS, METHODS, AND SYSTEMS FOR PATERNITY DETERMINATION
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机译:亲子率测定的组合物,方法和系统
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摘要
This application provides methods and systems for paternity determination. In some embodiments, the method is a non-invasive prenatal paternity determination method, which comprises obtaining genotypes for one or more polymorphic nucleic acid targets in a genomic DNA sample obtained from an alleged father, isolating cell-free nucleic acids from a biological sample obtained from the pregnant mother comprising fetal nucleic acids. The amount of each allele of one or more polymorphic nucleic acid targets in cell-free nucleic acids are determined and informative polymorphic nucleic acid targets are identified. Next, the allele frequency of each allele of the selected informative polymorphic nucleic acid targets is measured and fetal genotypes for each selected informative polymorphic nucleic acid targets are determined based on the allele frequency. Finally, the paternity status of the fetus are determined based on the genotypes of the mother, alleged father and the fetus for the informative nucleic acid targets.
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