A MOLECULAR GLUE REGULATING CDK12-DDB1 INTERACTION TO TRIGGER CYCLIN K DEGRADATION

摘要

Provided is a new kind of molecular glues for triggering polyubiquitination and degradation of CCNK (cyclin K). Specifically, a new kind of molecular glues for creating a modified CDK12 protein so as to bind DDB1 of DDB1-CUL4-RBX1. The molecular glues convert CDK12 into a substrate-specific receptor to trigger the polyubiquitination and subsequent degradation of CDK12's partner protein CCNK.