METHODS AND COMPOSITIONS FOR DETECTING STRUCTURAL REARRANGEMENTS IN A GENOME

摘要

Disclosed are compositions, kits, and methods for detecting gene fusions involving an unknown fusion partner using locked nucleic acid primers. In some embodiments, the compositions include a compound including at least two nucleotide sequences which are joined, directly or indirectly, through a 5' to 5' linkage. In some embodiments, the compound further includes a spacer moiety and/or a cleavage moiety.