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IMPROVED POLYPEPTIDES CAPABLE OF CONVERTING SUBSTRATE 3-KETO- DEOXYNIVALENOL INTO 3-EPI-DEOXYNIVALENOL
IMPROVED POLYPEPTIDES CAPABLE OF CONVERTING SUBSTRATE 3-KETO- DEOXYNIVALENOL INTO 3-EPI-DEOXYNIVALENOL
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机译:改进的多肽能够将底物3-酮 - 脱氧苯酚转化为3- epi-脱氧酚苯酚
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摘要
The present invention relates to a method of converting 3-keto-DON into 3-epi-DON, reducing the content of DON in a composition comprising DON or of reducing the toxicity of a composition comprising DON as well as a method for converting a trichothecene comprising a 3-oxo group into a trichothecene comprising a 3-hydroxy group using one or more polypeptide(s) comprising or consisting of SEQ ID NO. 1 or a sequence having a sequence identity of at least 72.0 % to SEQ ID NO. 1. Also envisioned are feed or food additives or feed or food as well as pharmaceutical compositions comprising one or more polypeptide(s) comprising or consisting of a sequence of SEQ ID NO. 1 or a sequence having a sequence identity of at least 72.0 % to SEQ ID NO. 1 as well as the manufacture thereof. Encompassed are further polypeptide(s) comprising or consisting of a sequence of SEQ ID NO. 1 or a sequence having a sequence identity of at least 88.5 % to SEQ ID NO. 1. Also envisioned are host cells or plants.
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机译:本发明涉及将3-酮-ON转化为3-EPI-DON的方法,降低了包含唐或降低包含缺乏组合物的组合物的组合物的组合物的含量以及转换三胞内癸烯的方法的组合物中的含量 将3-氧代组包含在包含包含或由SEQ ID NO组成的一种或多种多肽包含或由SEQ ID NO组成的三羟基的三核基团中包含3-羟基。 1或具有至少72.0%的序列同一性至SEQ ID NO的序列。 1.还设想的是饲料或食品添加剂或饲料或食物以及包含一种或多种多肽的药物组合物,其包含由SEQ ID NO的序列组成。 1或具有至少72.0%的序列同一性至SEQ ID NO的序列。 1以及其制造。 包含的是另外的多肽,其包含或由SEQ ID NO序列组成。 1或具有至少88.5%至SEQ ID NO的序列同一性的序列。 1.还设想是宿主细胞或植物。
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