首页> 外国专利> NOVEL WEISSELLA CIBARIA STRAIN AND FOOD COMPOSITION FOR PREVENTING OR AMELIORATING OBESITY OR FATTY LIVER DISEASE, COMPRISING WHEY FERMENTATION PRODUCT THEREOF

NOVEL WEISSELLA CIBARIA STRAIN AND FOOD COMPOSITION FOR PREVENTING OR AMELIORATING OBESITY OR FATTY LIVER DISEASE, COMPRISING WHEY FERMENTATION PRODUCT THEREOF

机译:用于预防或改善肥胖或脂肪肝疾病的新型Weissella Cibaria菌株和食品组合物,包括其乳清发酵产物

摘要

The present invention relates to a Weissella cibaria KI35 strain with accession number KACC 81117BP exhibiting anti-obesity activity during whey fermentation; a food composition, a food additive composition, a pharmaceutical composition, and a feed composition for preventing or ameliorating obesity or fatty liver disease, comprising a whey fermentation product bioconverted with the strain; a method for preventing or treating obesity or fatty liver disease, comprising the step of administering the pharmaceutical composition to an individual; and a use of a composition comprising a whey fermentation product bioconverted with a Weissella cibaria strain. The whey fermentation product bioconverted with the Weissella cibaria KI35 strain in the present invention reduces a weight gain rate through inhibition of pancreatic lipase activity, inhibition of α-amylase and α-glucosidase activity, and inhibition of obesity cell differentiation, and reduces the expression of proteins and genes related to obesity and inflammation in organs such as the liver and adipose tissue, thereby exhibiting the effects of preventing, ameliorating, or treating obesity and fatty liver disease.
机译:本发明涉及一种乳酸中的Weissella Cibaria Ki35菌株,其在乳清发酵过程中表现出抗肥胖活性的kacc 81117bp;用于预防或改善肥胖或脂肪肝病的食品组合物,食品添加剂组合物,药物组合物和饲料组合物,其包含生物转化的乳清发酵产物;一种用于预防或治疗肥胖或脂肪肝疾病的方法,包括将药物组合物与个体施用的步骤;并使用包含生物谐波的乳清发酵产物的组合物,其用Weissella cibaria菌株进行生物转化。用本发明中的Weissella Cibaria Ki35菌株生物转化的乳清发酵产物通过抑制胰脂肪酶活性,抑制α-淀粉酶和α-葡糖苷酶活性,以及​​肥胖细胞分化的抑制来降低重量增益速率,并降低表达蛋白质和基因与肥胖和炎症有关的器官,如肝脏和脂肪组织,从而表现出预防,改善或治疗肥胖和脂肪肝病的影响。

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