Composition for treating liver fibrosis and treatment method for liver fibrosis

摘要

PROBLEM TO BE SOLVED: To inhibit the expression of a double-stranded ribonucleic acid (dsRNA) composition targeting a COL1A1 gene, a TGF-β gene, or a SMAD2 / 3 gene, and COL1A1, TGF-β, or SMAD2 / 3. Provided is a method of using the dsRNA composition for the purpose. A dsRNA for inhibiting the expression of COL1A1, TFGβ, or SMAD2 / 3, wherein the dsRNA contains a sense strand and an antisense strand, and the sense strand is 3 or less with a specific nucleotide sequence. The antisense strand comprises at least 15 contiguous nucleotides with different nucleotides and the antisense strand comprises at least 15 contiguous nucleotides with 3 or less nucleotides different from the antisense nucleotide sequence corresponding to a particular sequence. dsRNA. [Selection diagram] FIG. 13