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DRUG CONJUGATE HAVING ENHANCED DRUG DELIVERY AND INTERNALIZATION EFFICIENCY
DRUG CONJUGATE HAVING ENHANCED DRUG DELIVERY AND INTERNALIZATION EFFICIENCY
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机译:药物缀合物具有增强的药物递送和内化效率
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摘要
The present invention relates to a unit-drug conjugate characterized in that a binding group, which enables binding to another unit-drug conjugate, is additionally connected to the unit-drug conjugate in which a drug is connected to a targeting material specifically binding to a target cell. When the unit-drug conjugate of the present invention is sequentially administered into the body, linkers form a cluster by means of in vivo cross-linking, and the cluster promotes endocytosis of the drug conjugate and thus notably enhances the cellular internalization of the drug comprised in the drug conjugate.
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