TYPE I-C CRISPR SYSTEM FROM NEISSERIA LACTAMICA AND METHODS OF USE

摘要

The disclosure provides a method of altering a DNA sequence, which method comprises the use of a type I-C CRISPR-Cas system based on Neisseria lactamica. The system involves a combination of two or more Neisseria lactamica proteins selected from Cas3, Cas5, Cas8c, and Cas7 and a synthetic guide RNA sequence.