Anti Fc epsilon - R1 alpha (FCER1A) antibody, double specific antigenic molecule binding to FCER1A and CD3, and their use

摘要

The present invention provides a novel full-length human antibody (single specificity antibody) that binds to human Fc epsilon R1 alpha.The invention also provides a novel dual specificity antibody (BsAb) that binds to both FC ipsilon R1 alpha and CD3 and activates T cells through the CD3 complex in the presence of cells expressing Fc epsilon R1 alpha.The dual specific anti binding molecule of the present invention is useful for the treatment of diseases and disorders that are controlled or induced by the Fc epsilon R1 alpha targeted immune response and are beneficial and / or therapeutic.For example, the dual specificity antibody of the present invention is useful for the treatment of allergy including anaphylaxis.No selection