Micronide dolalay patch with glucose responsive matrix for closed loop insulin delivery

摘要

Disclosed are compositions and methods of microneedle patches containing copolymers designed for glucose induced insulin delivery.In one aspect,Disclosed herein areMicroneedle patch containing an internal row copolymerInsulin aboveDissociated from the microneedle in the hyperglycemic environmentThe above copolymerIncluding poly (N-vinylpyrrolidone co - 2 - (dimethylamino) ethyl acrylate co - 3 - (acrylamide) phenylboronic acid)Microneedle patch and their use.