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MICRONEEDLE-ARRAY PATCHES WITH GLUCOSE-RESPONSIVE MATRIX FOR CLOSED-LOOP INSULIN DELIVERY
MICRONEEDLE-ARRAY PATCHES WITH GLUCOSE-RESPONSIVE MATRIX FOR CLOSED-LOOP INSULIN DELIVERY
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机译:微针阵列与葡萄糖响应矩阵用于闭环胰岛素递送的贴片
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摘要
Disclosed are compositions and methods for microneedle patches comprising copolymer designed for glucose triggered insulin delivery. In one aspect, disclosed herein are microneedle patches comprising insulin loaded copolymers; wherein the insulin dissociates from the microneedle in an hyperglycemic environment; wherein the copolymer comprises poly(N-vinylpyrrolidone-co-2-(dimethylamino)ethyl acrylate-co-3-(acrylamido)phenylboronic acid and methods of their use.
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