NEOANTIGENS CREATED BY ABERRANT-INDUCED SPLICING AND USES THEREOF IN ENHANCING IMMUNOTHERAPY

摘要

The invention relates to methods, compositions, and splicing modulating agents comprising nucleic acid sequences, specifically, antisense oligonucleotides and gene editing compounds. The splicing modulating agents of the invention are used in methods for producing neoantigens in subjects suffering from neoplastic disorders, by the induction of aberrant splicing events. The modulators of the invention are further used by the invention in enhancing immunotherapy.