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TURBIDITY NORMALIZATION ALGORITHM AND METHODS OF REDUCING INTRALIPID/LIPEMIA INTERFERENCE IN HEMOGLOBIN A1C ASSAYS
TURBIDITY NORMALIZATION ALGORITHM AND METHODS OF REDUCING INTRALIPID/LIPEMIA INTERFERENCE IN HEMOGLOBIN A1C ASSAYS
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机译:浊度归一化算法及降低血红蛋白A1C测定中的肿瘤内/脂质血症干扰的方法
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摘要
A method of spectroscopically measuring percent glycated hemoglobin or a glycated hemoglobin:total hemoglobin ratio in a biological sample is disclosed. The method includes the use of a turbidity normalization algorithm to normalize the total hemoglobin concentration calculated from the spectroscopic measurements to substantially remove any turbidity interference therefrom. The turbidity normalization eliminates the negative bias observed with intralipid/lipemia and thus provides a glycated hemoglobin assay with no significant interference from intralipid/lipemia.
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