BIFUNCTIONAL COMPOUND AND PHARMACEUTICAL COMPOSITION CAPABLE OF INDUCING DEGRADATION OF CORE SUBUNITS OF PRC2 PROTEIN COMPLEX, AND USE

摘要

Disclosed are a bifunctional compound and a pharmaceutical composition capable of inducing the degradation of the core subunits of the PRC2 protein complex, and the use. The bifunctional compound comprises a compound as shown in any one of formulas I-III, a pharmaceutically acceptable salt or a prodrug thereof, a solvate thereof, a hydrate thereof, a polymorph thereof, a tautomer, a stereoisomer, or an isotope substituted compound thereof. In the formulas I-III, n is an integer of 1-10, X is O, N or S and Y is O, H2 or S. The bifunctional compound can induce the degradation of the core subunits of the PRC2 protein complex, thereby achieving the treatment of cancers mediated by PRC2 complex and subunits thereof, EZH2, EED, SUZ12, RbAp46 and RbAp48, and blocking the carcinogenic activity of the subunits of the PRC2 complex.