2 2 Target protein degradation inducing compound preparation method thereof and pharmaceutical composition for preventing or treating EED EZH2 or PRC2 related diseases containing the same as an active ingredient

摘要

The present invention relates to a target proteolytic induction degrader, a method for producing the same, and a pharmaceutical composition for preventing or treating EED, EZH2, or PRC2 related diseases containing the same as an active ingredient. The novel compounds represented by Formula 1 according to the present invention include cereblon E3 ubiquitin ligase, von Hippel-Lindau tumor suppressor (VHL) E3 ubiquitin ligase, MDM2 (Mouse double minute 2 homolog) E3 ubiquitin ligase, As a degraducer compound that induces the degradation of a target protein, that is, EED (embryonic ectoderm development) or PRC2 (polycomb repressive complex 2) using cIAP (Cellular Inhibitor of Apoptosis Protein 1) E3 ubiquitin ligase, There is an aspect of remarkably achieving target protein degradation inducing activity through UPS (Ubiquitin Proteasome System), and a pharmaceutical composition for the prevention or treatment of target protein-related diseases or conditions containing it as an active ingredient, and health for prevention or improvement There is a useful effect that can provide a nutraceutical composition.