THIN, FLEXIBLE WEARABLE IMMUNOSENSOR FOR DETECTION OF MULTIPLE BIOMARKERS/TARGETS IN BODILY FLUIDS

摘要

The invention provides a layered dressing comprising: permeable wound contact layer for placing in contact with a wound; a breathable barrier layer; a biosensor sensing array configured to detect one or more markers in wound fluid; and a fluid collection layer disposed between the wound contact layer and a breathable barrier layer and configured to deliver wound fluid by capillary action from a wound in contact with the wound contact layer to the biosensor array. In a preferred embodiment, the layered dressing comprises aptamer-based electrodes for detecting TNF-α, IL-6, IL-8, TGF-β and an epitope of S. aureus.