Devices for treating, suppressing, or preventing a patient's eye disease can include a cover, which provides a cavity between the cover and the anterior surface of the eye when the cover is placed over the patient's eye. Has a size and shape that fits the patient's eye to demarcate. The device can include a pressure source that communicates with the cavity and is capable of applying non-atmospheric pressure within the cavity. The device is applied to the cavity to communicate with the pressure source to influence the target pressure relationship between the index of the first physiological pressure level associated with the patient's eye and the second physiological pressure level. It can include a control circuit configured to change the non-atmospheric pressure.
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