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Synthesis Of Enzyme-Polymer Conjugates, Having Enhanced Activity Stability
Synthesis Of Enzyme-Polymer Conjugates, Having Enhanced Activity Stability
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机译:合成酶 - 聚合物缀合物,具有增强的活性和稳定性
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摘要
A process for site-specific immobilization of an enzyme on a polymer involving pairing of an enzyme and polymer to optimize cross-linking between the enzyme and the polymer while avoiding conformational or biochemical inhibition of enzyme activity. The process involves site specific interaction in a multiple phase synthesis within a buffered reaction medium and in an inert atmosphere. The reaction kinetics of the conjugation are modulated by chilling the reaction medium containing the enzyme and polymer to about the maximum solvent density of the reaction medium. The cross-linking of the enzyme and a polymer pair performed produces an enzymatically active, stable conjugate.
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