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A method for assisting in the diagnosis of Niemann-Pick disease type C, a method for assisting in determining the therapeutic effect on Niemann-Pick disease type C, and a method for screening a drug for treating Niemann-Pick disease type C.
A method for assisting in the diagnosis of Niemann-Pick disease type C, a method for assisting in determining the therapeutic effect on Niemann-Pick disease type C, and a method for screening a drug for treating Niemann-Pick disease type C.
To provide markers and methods which can determine therapeutic effect on lysosomal diseases and to provide screening methods for lysosomal disease therapeutic agents.SOLUTION: A marker is a sugar chain which is selected at least one from the group consisting of CS-2S4S, HS-0S, HS-NS, HS-2S6S which are glycosaminoglycan, (Hex)3(HexNAc)1-(Hex)8(HexNAc)1, (Hex)1(HexNAc) 2, (Hex)4(HexNAc) 2-(Hex)6(HexNAc)2 which are free oligosaccharide, the total amount of high mannose type Gn1, the total amount of pouch mannose type Gn2, the total amount of high mannose type Gn2, the total amount of a compound type/hybrid type, (Hex)3(HexNAc)3, (Hex)3(HexNAc) 2(NeuAc)1, (Hex)4(HexNAc)2(Fuc)1, (Hex)4(HexNAc)3, and (Hex) 5(HexNAc)4.SELECTED DRAWING: Figure 7
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