45-d-2- NOVEL PYRIMIDO45-dPYRIMIDIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS

摘要

The present invention relates to a pyrimido[4,5-d]pyrimidin-2-one derivative compound exhibiting excellent antiproliferative efficacy against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate or stereoisomer thereof, and a method for preparing the same; It relates to a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative disease containing the same as an active ingredient, and an anticancer composition for cancer cells, wherein the compound exhibits excellent anti-cancer activity and anti-proliferative efficacy, so that cancer cell inhibition is Furthermore, it is useful for preventing cancer metastasis and proliferative diseases or treating cancer.